We develop innovative noninvasive biotechnologies and molecular tools to precisely control and monitor intact brain cells and tissues in their native environments, advancing our understanding of brain function in health and disease. By integrating therapeutic ultrasound, protein engineering, neuropharmacology, and bioinformatics, we aim to achieve unprecedented spatial, temporal, and molecular precision in controlling and monitoring endogenous molecular processes while preserving the brain's natural environment. Our vision is to transform how we study and control the brain, advance fundamental neuroscience, and pioneer precise, noninvasive therapies for brain disorders.